In a major shift for the fashion world, Donatella Versace has announced her decision to step down as creative director of Versace, a role she took on after the tragic death of her brother Gianni Versace in 1997.

Reflecting on her decades-long tenure, Donatella wrote on Instagram: “It has been the greatest honor of my life to carry on my brother Gianni’s legacy. He was the true genius, but I hope I have some of his spirit and tenacity.”

As she embraces a new role as chief brand ambassador, her departure marks the end of an era, with Dario Vitale, formerly of Miu Miu, stepping in as the brand’s new top creative officer.

“I am thrilled that Dario Vitale will be joining us, and excited to see Versace through new eyes,” she wrote. “In my new role as Chief Brand Ambassador, I will remain Versace’s most passionate supporter. Versace is in my DNA and always in my heart.”

Donatella’s impact on fashion remains undeniable. Her visionary designs not only defined the pop culture of the early 2000s but also cemented her reputation as a force in luxury fashion.

Here’s a look back at some of her most famous designs on the red carpet and beyond—and what she and the stars who wore them had to say about the looks.